THC-O: The Newest Cannabinoid

THC-O Beaker

Federally legal hemp-derived cannabinoids have exploded in popularity due to the still-illegal status of cannabis and Delta 9 THC in most states. Cannabinoids like CBD, CBN, and Delta 8 THC were some of the first to gain traction offering consumers the relief on par with medical cannabis at a fraction of the cost. The science of hemp has significantly progressed and newer, less researched cannabinoids like THC-O have now hit the market. THC-O Acetate is for sale on most hemp sites, but selecting the right one can be tricky. THC-O promises increased bioavailability and potency, but what is it, and what are its applications in comparison to these other legal cannabinoids?

Table of Contents

THC-O Discovery
What is THC-O Acetate?
Difference between THC-O and THC-A
Kinds of O Acetate
Can O Acetate Be Ingested
Can you vape/dab THC-O

Discovery of THC-O

Most people would point you to the direction of the Author. D. Gold, who spurred the interest of many in his book Cannabis Alchemy: Art of Modern Hashmaking, a book where he described the synthesis of making THC-O. 

What is THC-O Acetate?

It is the Acetate ester form of THC. It differs from traditional THC mainly because of its increased ability to be absorbed into fats or oils, making it more bioavailable than traditional THC. 

Difference between THC-O Acetate and THCA Acid

THC-O Acetate is already activated in a sense of being able to be consumed so you do not have to decarb it like THCA to feel the effects as an edible. THCA has an added carboxyl group to it that regular THC doesn’t have. Because of this, THCA doesn’t bind to the CB1 receptors like THC does, in order for this process to happen the molecules have to go through the process of decarboxylation. Decarboxylation is a scientific way of saying applying enough heat to remove the carboxyl group so it then converts into THC. 

Kinds of O Acetate

Currently there are 2 kinds of Acetate being produced. The main one is Delta 8 O Acetate. The second is Delta 9 O Acetate. The biggest difference is that D9OA is found in the Cannabis plant whereas the D8OA has to be synthesized to be available. There is a THC-O phosphate that is water soluble and the ester form of THC-O which is dabbable and vapeable.

Can O Acetate Be Ingested?

The other method is consuming the distillate with high amounts of fat to help increase absorption and aid in bioavailability. These items can include peanut butter, hazelnut spread, and even chocolate. The distillate can even be infused into baked goods like cookies.

Can you vape/dab THC-O?

Vaping or dabbing THC-O can be done just like you can with other readily available Deltas. It can even be infused with terpenes to give the distillate Indica or Sativa effects. The most common method is vaporizing the distillate by a process most call “dabbing”. Dabbing can be done from a device like an enail or using a butane torch to apply heat to the banger. The banger is attached to a water pipe, which diffuses the smoke into water which is then inhaled by the user. The most common method for vaping it is by filling the distillate into a 510 threaded vape cartridge and using what is commonly known as a “vape battery” to apply power to said cartridge to vape it. 


While this may be a new cannabinoid on the market, we aim to provide every bit of information on it to shed some light and take the anxiety and fear out of its debut. Some may say that THC-O is entirely synthetic and has no place on the shelf next to Delta 9, CBD, and other naturally occurring phytocannabinoids, but we believe that it is just as therapeutic and beneficial as the more well-known cannabinoids that are available now. Some users may not feel Delta 8 or Delta 9 edibles, and THC-O may finally bring that relief to those individuals who still cannot smoke or vape understandably. We hope bringing more research to the table will open up the discussion on how to use these cannabinoids safely and effectively, and what their future applications might be for cannabis and hemp users alike.

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Comments (4)

  • Kathie Reply

    Is my decarboxylated THCO flower that I made a tincture out of already now useless? I have since discovered that you’re not supposed to decarb it but I did unfortunately thank you in advance

    July 4, 2022 at 9:33 am
    • Alec Reply


      To make THC-O products at home, we strongly recommend using bulk THC-O acetate to get the most potency out of your end result. Decarbing THC-O and Delta-8 infused flower will not be as efficient, but you still will be getting some of the cannabinoids infused in the flower, so it’s not a total waste. You will also be getting the active CBD and other cannabinoids found in the flower, making it more of a full-spectrum product.


      July 4, 2022 at 12:32 pm
      • Jorge Reply

        How do I make thc o coconut oil?

        October 4, 2022 at 12:18 pm
        • Alec Reply

          Hi Jorge,

          You can make THC-O infused coconut oil very easily! All it requires is your preferred amount of THC-O distillate, then you heat both the distillate and the coconut oil (never above 160f, usually in the 140-160f range), and mix together. Since THC-O and other cannabinoids are fat-soluble, it blends and absorbs into the coconut oil very easily after some thorough mixing.

          Alec with Snapdragon Hemp

          October 4, 2022 at 12:21 pm

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